Ochratoxin A (OTA) is a toxic secondary metabolite of small molecular weight mainly produced by Aspergillus and Penicillium species, which are widely found in food, agricultural products and animal feed. It has strong hepatotoxicity, nephrotoxicity, teratogenic and mutagenic effects, and is also a class ⅡB carcinogens. In view of OTA's universality and harmfulness, the present situation of the commonly used detection methods of OTA is summarized and compared in this paper. Specifically, the application of new electrochemical aptasensor in OTA detection is mainly described. OTA electrochemical aptasensors are divided into three categories:configuration transformation type, affinity type and hybrid type. Their respective principles, characteristics and the latest research progress are discussed in detail. Furthermore, the summary of the future directions and the potential applications are given, which provides reference for the further research and application of OTA.
Contents
1 Introduction
2 Traditional detection technology of OTA
3 Electrochemical aptasensor for OTA
3.1 Configuration conversion type electrochemical aptasensor
3.2 Affinity electrochemical aptasensor
3.3 Hybrid type electrochemical aptasensor
4 Conclusion and outlook