Heterocyclic ketene aminals (HKAs) are a class of fascinating and versatile synthetic building blocks for use in the construction of a wide range of molecular diversity fused heterocyclic compounds and synthetic drugs. With the further development of HKAs, great progress has been made in reactions of HKAs as a binucleophilic reagents with a variety of electrophilic substrates. Based on the structural characteristics and reaction performances of HKAs, construction of a variety of potentially bioactive natural-like polycyclic heterocyclic compounds with HKAs and 1,1-enediamine as synthons is reviewed herein.
Contents
1 Introduction
2 Construction of natural-like polycyclic fused heterocyclic compounds with pyrrole as the core skeleton of the molecule
2.1 Construction of multi-substituted bicyclic pyrrole derivatives
2.2 Construction of polycyclic pyrrole derivatives
3 Construction of polycyclic fused heterocyclic compounds with pyridine as the core skeleton of the molecule.
3.1 Construction of bicyclopyridine derivatives
3.2 Construction of polycyclic pyridine derivatives
4 Construction of polycyclic fused heterocyclic compounds with indole as the core skeleton of the molecule
5 Construction of polycyclic fused heterocyclic compounds with quinoline as the core skeleton of the molecule
6 Construction of natural polycyclic fused heterocyclic compounds with bridge and spiro analogues as the core skeleton of the molecule
7 Construction of other types of polycyclic fused ring heterocyclic compounds
8 Conclusion and outlook