Development and application of hybrid magnetic biomaterials has been attracting great attention in biomedical applications. Magnetic nanoparticles (MNPs) have emerged as a promising theranostic tool for diagnostic imaging, drug delivery and novel therapeutics because of their functionalization, targeted delivery, controllable drug release and image-guided capabilities. Remotely triggered magnetic drug delivery systems based on MNPs or doped iron oxides can enhance the drug delivery efficiency to the cancerous regions with low toxicity or without toxicity to the surrounding healthy cells. In order to fabricate safer and more effective magnetic drug delivery systems, different materials or ligands such as biomolecules, polymers even natural extractive are combined with MNPs by this hybrid approach, which has created entirely new advanced compositions with truly unique properties for drug delivery. So far, the responsive nano-structured magnetic drug delivery carriers have been extensively explored for remotely controlled drug release although there are still some difficulties and challenges. In this review, we summarize the recent advances in the design and fabrication of hybrid magnetic drug delivery carriers as remotely controlled therapeutic systems with a focus on the materials for delivery carriers fabrication including phospholipid molecules, polymers, mesoporous micro-nanomaterials, natural extractive, etc. In addition, the advantages, limits and prospects of current hybrid targeted magnetic drug delivery carriers are also briefly summarized.
Contents
1 Introduction
2 Fabrication and application of magnetic response drug delivery carriers
2.1 Drug delivery carriers based on phospholipid and magnetic nanoparticles
2.2 Drug delivery carriers based on polymer and magnetic nanoparticles
2.3 Drug delivery carriers based on porous micro-nanomaterial and magnetic nanoparticles
2.4 Drug delivery carriers based on natural extractive and magnetic nanoparticles
3 Conclusion