The compounds with aggregation-induced emission (AIE) property have been widely developed to solve aggregation-caused quenching (ACQ) problem of organic luminophores at high concentration, in the solid state, or in the form of thin film. Therefore, AIE compounds are useful for a number of applications, such as fluorescent probes and receptors, and cell imaging. Tetraphenylethene (TPE) and its derivatives, as typical compounds with AIE property, have been widely applied in materials chemistry, biochemistry, and other related fields. Inspired from AIE, TPE has been also introduced into the field of supramolecular chemistry by supramolecular chemists. Especially, given their ability to restrict the intramolecular rotation or motion of TPE molecules, macrocyclic hosts can form host-guest complexes or supramolecular polymers with TPE via host-guest interactions, which results in enhancement in the AIE effect of guests. Hence, AIE of TPE derivatives with macrocycles via host-guest interaction also provides a new approach to develop the applications in stimuli-responsive sensors and probes. This review mainly focuses on summarizing the research progress of host-guest complexes between macrocycles and TPE, and comments on the bright future of AIE behaviors of the supramolecular systems involving host-guest interactions.