Hydrogen bond is one of the most basic weak interaction of natural intermolecular forces and the ideal driving force for constructing supramolecular self-assembly systems. In the past few years, the construction of excellent multiple hydrogen bonded building blocks has become a hot research direction in supramolecular chemistry. Among that, quadruple hydrogen bonded systems are widely used for the construction of supramolecular assemblies due to their several advantages, such as strong binding power, simple synthesis, easily modifiable structure, and predictable recognition performance. In this review, we aim to provide a broad overview of the progress of quadruple hydrogen bonded systems. More specifically, we emphatically elaborate the design principles and applications of various typed quadruple hydrogen bonded systems.