Hematological malignancies(HM) is a kind of malignant disease of hematology system which seriously threatens human health, mainly involving bone marrow, blood and lymphatic tissue. The quantification of biomarkers in hematological malignancies is the key for fine stratification analysis, personalized targeted therapy and prognostic improvement. In this paper, the specific types and the commonly used detection methods at home and abroad of the hematological malignancies related biomarkers are summarized and compared. Specifically, the latest application of new electrochemical biosensor for the hematological malignancies related biomarkers is mainly described. Furthermore, the summary of its future directions and the potential applications is given, which provides reference for the further research and application of the biomarkers in hematological malignancies.