Mn-Ce binary oxide has been considered as a kind of outstanding materials and widely applied to many fields by the reasons of abundance, low cost, excellent oxygen storage and release capability and high catalytic performance. In this review, the preparation and applications of Mn-Ce binary oxides have been reviewed in detail. Preparation methods including precipitation method, sol-gel method, hydrothermal method, impregnation method, and so on, are summarized. Meanwhile, their merits and demerits are compared. As for applications, air pollution removal(NO_x, VOCs, CO, soot, Hg⁰and formaldehyde) and energy storage systems(supercapacitors and metal-air batteries) are overviewed particularly. In addition, the applications of water pollution disposal(fluoride adsorbed, As(Ⅲ) removal, methyl orange degradation) and organic catalytic synthesis are introduced briefly. Finally, the main problems of preparation methods of Mn-Ce binary oxides are discussed and the research directions are forecast.