Traditionally, calcium carbide is a widely used raw material in organic synthesis. It is always first converted into acetylene gas and subsequently used to prepare organic compounds. Acetylene gas is inflammable and explosive, posing the problem of storage and transportation. In addition, directly using acetylene gas as precursor needs harsh reaction conditions and complicated operation, which greatly limits its further application. Recently, it is shown that calcium carbide could be quickly prepared from renewable biochar at relatively low temperature. Such progress allows calcium carbide as a green and economical raw material. Therefore, the direct use of calcium carbide as a green acetylene source instead of acetylene gas and acetylene reagent to prepare various important organic chemicals will be a simple and green way. In this review, the major progress to date, as well as related reaction types and reaction mechanism towards the application of calcium carbide for specific organic reaction and synthesis have been summarized. The trend of using calcium carbide as a solid acetylene source to construct organic compounds is also prospected.