Natural products refer to the natural compounds produced by the secondary metabolism of the organism. Due to their good biocompatibility and various pharmacological activities, natural products are widely used in the fields of medicine, food, cosmetics, etc. Recently, some natural products with self-assembly capabilities have been discovered to form soft materials, natural product gels(NPG). Not exactly the same as the currently well-known gels(including synthetic low molecular mass gels, synthetic macromolecular gels, and natural macromolecular gels), NPG are natural(generally derived from traditional Chinese medicine) supramolecular gels. This makes NPG have good biological activity and responsiveness to external stimuli. Therefore, NPG have some inherent advantages in constructing biomedical materials and stimuli-responsive materials. In addition, studies of changes in the biological activity of different self-assembled NPGs can reveal the effects of self-assembly of natural products on biological activity. As such, the research and development of NPG is of great value. Here, we introduce the preparation, types, formation and application of NPG and their gelators, in an attempt to make people understand this emerging interdisciplinary research field.