Proton exchange membrane fuel cell(PEMFC) has attracted huge attention recently due to its high energy conversion efficiency, low operating temperature and environmental benign. With the launch of the Mirai fuel cell electric vehicle by Toyota in 2014, a new wave of industrialization of fuel cells and fuel cell vehicles has been brought about. However, enhancing the durability of PEMFC and developing a new generation of membrane electrode assembly(MEA) and fuel cells are still challenging topics in the field. The MEA is the core component of PEMFC, and its durability directly determines the life of the fuel cell. The MEA is mainly composed of a proton exchange membrane, anode and cathode catalyst layers and gas diffusion layers on both sides. In last decade, great efforts have been paid to improving the durability of MEAs/PEMFCs from three aspects, membrane, catalyst layer and gas diffusion layer. In this paper, we introduce these research works systematically, and a review and prospect for the research and development of this topic in the future is also made.