Two-dimensional Covalent organic frameworks(2D-COFs), as a new type of crystalline porous materials constructed with organic building blocks, possessing regular pore structure, good stability, high surface area and extended π-conjugation system, have shown good photoactivity and tremendous potential for light-driven chemical transformations. Therefore, the application of 2D-COFs in light-driven chemical transformations has recently garnered great attention in both porous materials science and photocatalysis. This review mainly summarizes and discusses the applications of photoactive 2D-COFs in light-driven chemical transformations in recent years. Future development is also prospected.