Chiral carbon quantum dots(CQDs) have wide application potential in catalysis, detection and biomedicine owing to their excellent fluorescence properties, good biocompatibility, low toxicity, easy functionalization and chiral characteristics. At present, chiral CQDs are synthesized by one-step or two-step methods, and applied to chiral catalysis, chiral detection, Golgi apparatus targeted imaging, selective tuning of enzyme and protein activity, selective regulation of cellular energy metabolism, promotion of plant growth, etc. However, the development of chiral CQDs is just beginning. It is necessary to further improve the controllable synthesis process and prepare long wavelength chiral CQDs with high fluorescence quantum yield, so as to make them shine brilliantly in biomedical and other fields.