Application of Viscoelastic Fluid in Passive Particle Manipulation Technologies
Chen Ni , Di Jiang , Youlin Xu , Wenlai Tang
Progress in Chemistry ›› 2020, Vol. 32 ›› Issue (5) : 519 -535.
Microfluidics, which can precisely manipulate micron-sized particles, has been widely used in medical, pharmaceutical, biological and chemical fields. The passive manipulation technologies without external field effect have become a research hotspot because of their simplicity and autonomy. Compared with other passive manipulation technologies, viscoelastic focusing technology makes it easier to achieve three-dimensional focusing of particles, and can manipulate particles with a large-scale span and a wide range of fluid flow. Therefore, this paper reviews the latest research on viscoelastic fluids in particle passive manipulation applications. Firstly, the force mechanism of particles in viscoelastic fluid in different microchannel structure is introduced. Then, the research progress of viscoelastic focusing, sorting, mixing and other viscoelastic particle manipulation applications is further elaborated. Finally, the numerical simulation method for studying the flow characteristics of viscoelastic fluids and the movement law of particles in it are introduced, and some prospects for the future development of viscoelastic microfluidics are made based on the analysis of existing problems.
1 Introduction
2 Viscoelastic focusing
2.1 Viscoelastic focusing in straight microchannels
2.2 Viscoelastic focusing in curved microchannels
3 Viscoelastic sorting
3.1 Sheath-flow sorting
3.2 Sheath-free sorting
4 Other applications
5 Numerical simulation
6 Conclusion and prospects
viscoelastic fluid / microfluidics / particle focusing / particle sorting / numerical simulation
National Natural Science Foundation of China(51805270)
National Natural Science Foundation of China(51805272)
Key Technology R&D Program of Jiangsu Province(BE2018010-1)
Key Technology R&D Program of Jiangsu Province(BE2018010-2)
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