Cyclodextrin has gained great attention since its discovery, due to its special cavity structure. Combining the cavity with multi-hydroxyl groups of cyclodextrin and the multi-arms of star-like polymer, a star-like polymer based on cyclodextrin has three-dimensional structure, special functional groups and features of cyclodextrin. These make star-like cyclodextrin polymers possess wide application and great development potential. Herein, this review summarizes the preparation methods of star-like polymer using cyclodextrin as reaction center, and the corresponding applications in biomedical, electrochemistry, wastewater treatment and other aspects. Furthermore, the new research trends and development direction of star-like polymer based on cyclodextrin are presented.