Stemona alkaloids are a class of alkaloids isolated from the roots of Stemona sessilifolia and its related plants. In terms of molecular structure, stemona alkaloids generally have [1, 2-b]pyrrolo[1, 2-a]azepine as the core structure. The substitutions at different positions on the core scaffold afford various complex structures which exhibit many important biological activities. Therefore, the research on the total synthesis of the stemona alkaloids has attracted the attention of chemists worldwide. However, due to the polycyclic structure and multiple chiral centers in the structure of stemona alkaloids, the total synthesis of stemona alkaloids is extremely challenging. In recent years, chemists have developed the reactions with high enantioselectivity and tandem reactions to complete the total synthesis of the stemona alkaloids, which has laid a solid foundation for further research and development of the stemona alkaloids. Based on the relevant research of our research group, this paper reviews the recent effort on the total synthesis of various types of stemona alkaloids.

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