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Investigation into Condensed-Matter Organic Synthesis under Mechanical Milling Conditions
Nana Wang , Guanwu Wang
Progress in Chemistry ›› 2020, Vol. 32 ›› Issue (8) : 1076 -1085.
Investigation into Condensed-Matter Organic Synthesis under Mechanical Milling Conditions
Nana Wang , Guanwu Wang
Progress in Chemistry ›› 2020, Vol. 32 ›› Issue (8) : 1076 -1085.
Mechanochemical activation achieved by milling, shearing or pulling opens up new opportunities in synthetic chemistry. Mechanical milling, which is a green solvent-free synthetic methodology, has wide application prospects. In this review, we present the current status and future prospect of mechanochemical organic reactions in condensed matters such as solid state or sticky reaction mixture. Compared with traditional liquid-phase counterparts, mechanochemical condensed-matter organic reactions have the advantages of no usage of solvent, high reaction efficiency, short reaction time, lower reaction temperature, good selectivity, simple post-treatment, and suitability for substrates with poor solubility. In some mechanochemical organic reactions, different reaction products are generated miraculously, especially those not available in liquid-phase counterparts.
===1 Introduction
===2 Typical examples of condensed-matter organic reactions under ball-milling conditions
===2.1 Cases with reduced reaction time and reaction temperature
===2.2 Cases with selectivity enhancement
===2.3 Cases with different reaction pathways
===3 Main issues of condensed-matter organic reactions under ball-milling conditions
===3.1 Milling apparatus
===3.2 Milling media and frequency
===3.3 Liquid-assisted grinding(LAG) and grinding auxiliary
===3.4 Mechanochemical reaction mechanisms: in situ monitoring
===4 Conclusion and outlook
mechanochemistry / mechanical milling / condensed-matter organic synthesis
the National Natural Science Foundation of China(21372211)
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