As an important unit of molecular structure and organic building blocks, the development of new synthetic methods of allene has received much attention. The Heck and related cascade reaction of alkenes is arguably one of the most synthetically versatile method. However, the Heck reaction of alkyl-alkynes leading to allenes has lagged behind due to the energetically unfavored β-hydride elimination of vinyl palladium species. Several competitive reactions such as protonation, carbohalogenation and cascade reaction exist. Moreover, the isomerization of allene and the regioselectivity of unsymmetrical alkyl-alkynes also limited this research progress. To effectively promote β-hydride elimination of vinyl palladium species, several commonly-used strategies are the increasing reaction temperature, introduction of ortho-substituent to aryl halides and the development of ligand. In this mini-review, Heck and related reaction of alkyl-alkynes including β-hydride elimination reactions of vinyl palladium species, protonation reaction, carbohalogenation reaction, and cascade reaction are emphasized. Finally, the major limitation and an outlook this type of reaction are provided.