Quinoproteins are an important type of redox enzymes for the oxidative metabolism of alcohols and amines, which employ ortho-quinones as the cofactors. On the basis of catalytic principles and strategies of quino-enzymes, a number of molecular quinone catalysts have been developed during the past two decades. With copper amine oxidases(CuAOs) as a blueprint, small molecular ortho-quinone catalysts have been developed for amine oxidation. These catalysts could mimic the catalytic performance of CuAOs, and expand the substrate scope to α-branched primary amines, secondary amines and tertiary amines. Recent studies have also uncovered a new type of quinoproteins, methanol dehydrogenase(MDH), utilizing rare earth elements as the active metal. In this review, we summarize the major types of quinoproteins, the development of their mimics ortho-quinone catalyst as well as perspective on the future development of bio-inspired ortho-quinone catalysis.