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Recent Advances on Tandem Hydroformylation of Olefins

Peng Wang , Huan Liu , Da Yang

Progress in Chemistry ›› 2022, Vol. 34 ›› Issue (5) : 1076 -1087.

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Progress in Chemistry ›› 2022, Vol. 34 ›› Issue (5) : 1076-1087 DOI: 10.7536/PC210522
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Recent Advances on Tandem Hydroformylation of Olefins
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Abstract

Tandem hydroformylation reaction is based on hydroformylation, with one or more different types of reactions "one pot" to achieve the follow-up directional conversion of aldehydes, to get new organic molecules. The products have very important applications in the production of daily chemical industry, agriculture or medical intermediates. In this paper, the importance of olefin tandem hydroformylation to prepare high value-added chemicals in recent years is briefly introduced, then several common tandem hydroformylation (Tandem “Isomerization-hydroformylation”, Tandem “Hydroformylation-acetalization”, Tandem “Hydroformylation-hydrogenation”, Tandem “Hydroformylation-(reductive) amination”) in the design of new (multifunctional) catalyst systems and efficient synthesis of target products are introduced. Finally, the existing problems and future development of the reaction are prospected.

Contents

1 Introduction

2 Tandem “isomerization-hydroformylation”

3 Tandem “hydroformylation-acetalization”

4 Tandem “hydroformylation-hydrogenation”

5 Tandem “hydroformylation-(reductive) amination”

5.1 Tandem “hydroformylation-amination”

5.2 Tandem “hydroformylation-reductive amination”

6 Other types of tandem hydroformylation reaction

7 Conclusion and outlook

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Keywords

olefins / hydroformylation / tandem reaction / syngas / homogeneous catalysis

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Peng Wang, Huan Liu, Da Yang. Recent Advances on Tandem Hydroformylation of Olefins. Progress in Chemistry, 2022, 34(5): 1076-1087 DOI:10.7536/PC210522

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Funding

National Natural Science Foundation of China(21901250)

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