Coenzyme NADH-dependent oxidoreductases are widely used in the fields of fine chemical synthesis and chiral drug development. As a reducing equivalent, NADH plays a key role in oxidoreductase catalysis. In view of the stoichiometric consumption and high cost of NADH, the search for green, feasible and efficient coenzyme regeneration strategies is an important but challenging task. In recent years, photo/(electro)-catalytic method for NADH regeneration has received extensive attention. In this paper, starting from the Z-scheme reaction that simulates natural photosynthesis, based on the photo-induced electron transfer and hole capture in the process of photo/(electro)-catalytic coenzyme regeneration, some recent works related to NADH regeneration are reviewed. The review is expected to provide ideas for further design of efficient coenzyme regeneration system. In addition, the research progress on NADH-dependent photo-enzyme synergistic catalysis in recent years is also briefly introduced, and an outlook is tentatively attempted about the challenges of the biomimetic photocatalytic coenzyme regeneration system and the future developments of photo-enzyme coupling system.